Department / Division:
Medicine
/
Pulmonary, Allergy, and Critical Care
Address:
DUMC 3136
Durham, NC 27710
Appointment Telephone:
919-668-7630
Office Telephone:
919-684-4588
Fax Telephone:
919-684-3067
Clinical Interests:
Pulmonary fibrosis, asthma, COPD, sarcoidosis
Research Interests:
John W. Hollingsworth, MD, is an Assistant Professor in the Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine at Duke University Medical Center. He is a graduate of the University of Texas Medical Branch. He completed his residency and chief residency in Internal Medicine at University of Texas Medical Branch. His fellowship training was completed in Pulmonary and Critical Care Medicine at Duke University Medical Center. Dr. Hollingsworth completed his post-doctoral research training in the laboratory of Dr. David A. Schwartz in 2004, where he has characterized the role of toll-like receptor 4 in inhaled environmental toxin exposure. The broad objective of ongoing studies is to better understand the role of environmental exposures on genetic and epigenetic regulation of complex heritable diseases. Current studies investigate the role of maternal diet and epigenetic regulation of allergic asthma. In addition, we study the complex interaction between the innate immune system and the common inhaled toxicant, ozone. Current studies are focused on both understanding the role of innate immunity in environmental airways disease and how exposure to ambient ozone can modify subsequent innate/adaptive immune response in the lung. These lines of investigation will help us better understand the mechanisms, which lead to increased respiratory and cardiovascular mortality after exposure to ambient ozone.