Andrea M. Haqq, MD

Department / Division:
Pediatrics / Endocrinology

Address:
DUMC 3080
Durham, NC 27710

Appointment Telephone:
(919) 684-3772

Office Telephone:
(919) 684-8355

Fax Telephone:
(919) 684-8613

• M.D., University of Calgary, Canada, 1994

• Pediatrics, University of British Columbia, Canada, 1994-1997
• Pediatrics, University of Ottawa, Canada, 1998

• Pediatric Endocrinology, Oregon Health and Science University, 1998-2002

Clinical Interests:
General pediatric endocrinology, hypothalamic pituitary dysfunction, disorders of growth, thyroid function, sexual development, diabetes mellitus, Prader-Willi syndrome, and childhood obesity

Research Interests:
I have a basic and clinical translational research interest in disorders of nutrient balance in children including a number of disorders: childhood obesity, Prader-Willi Syndrome (PWS), hypothalamic-derived obesity, failure-to-thrive, cachexia, anorexia nervosa and bulimia.

My basic research interest to date has focused on understanding the molecular role of the melanocortin-4 receptor (MC4-R). This receptor plays a role in energy homeostasis in both rodents and humans. Disruption of the MC4-R in rodents and humans leads to an obesity syndrome characterized by hyperphagia, late-onset obesity, hyperinsulinemia and increased linear growth. I have utilized the yeast two-hybrid assay in order to discover which proteins interact directly with the MC4-R and therefore, understand more fully the signaling mechanism of the MC4-R.

My clinical translational research to date has centered on ghrelin, a newly described gastroenteric hormone that plays a key role in the long-term regulation of energy balance in humans. Myself and colleagues have shown that children with Prader-Willi Syndrome (PWS), a genetic obesity syndrome, exhibit 4-5 times increased fasting circulating ghrelin levels compared to healthy children matched for body mass index. We hypothesize that increased fasting ghrelin concentrations in PWS drives the chronic insatiable appetite and leads to the development of morbid obesity in individuals with this disorder.

Further translational clinical research goals include understanding ghrelin and other neuropeptides’ (adiponectin, Peptide YY, leptin) metabolism in the context of other childhood disorders of energy balance and during various dietary and therapeutic interventions for childhood obesity or cachexia states.

I am also currently a Co-investigator on The Study of the Effects of Diet on Metabolism and Nutrition (The STEDMAN study), lead by Co-PIs: Laura P. Svetkey and Christopher B. Newgard. This is an observational study that metabolically profiles obese subjects as they lose weight via several distinct interventions available at Duke University and the surrounding community.

Representative Publications:
Uckun-Kitapci A, Haqq AM, Purnell JQ, Newcomb K, Gulkesen H, Underwood LE. Serum ghrelin concentrations are increased in children with growth hormone insensitivity and decrease during long-term insulinlike growth factor-I treatment. J Investig Med. 2008 Jan;56(1):26-31. (2008) Abstract

Tantibhedhyangkul J, Copland SD, Haqq AM, Price TM. A case of female epispadias. Fertil Steril. 2008 Mar 1. (2008) Abstract

Rubin DA, McMurray RG, Harrell JS, Hackney AC, Thorpe DE, Haqq AM. The association between insulin resistance and cytokines in adolescents: the role of weight status and exercise. Metabolism. 2008 May;57(5):683-690. (2008) Abstract

Rubin DA, McMurray RG, Harrell JS, Hackney AC, Haqq AM. Do Surrogate Markers for Adiposity Relate to Cytokines in Adolescents? J Investig Med. 2008 Jun;56(5):786-792. (2008) Abstract

Haqq, AM. Prader-Willi Syndrome: A model of disordered energy homeostasis. In Energy Metabolism and Obesity: Research and Clinical Applications, Patricia A. Donohoue, editor. 2008. (2008)

Tanumihardjo SA, Anderson C, Kaufer-Horwitz M, Bode L, Emenaker NJ, Haqq AM, Satia JA, Silver HJ, Stadler DD. Poverty, obesity, and malnutrition: an international perspective recognizing the paradox. J Am Diet Assoc. 2007 Nov;107(11):1966-72. (2007) Abstract

Haqq AM, Muehlbauer M, Svetkey LP, Newgard CB, Purnell JQ, Grambow SC, Freemark MS. Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones. Clin Endocrinol (Oxf). 2007 Dec;67(6):944-51. (2007) Abstract

Gillingham MB, Purnell JQ, Jordan J, Stadler D, Haqq AM, Harding CO. Effects of higher dietary protein intake on energy balance and metabolic control in children with long-chain 3-hydroxy acyl-CoA dehydrogenase (LCHAD) or trifunctional protein (TFP) deficiency. Mol Genet Metab. 2006 Sep 20. (2006) Abstract

Geller DS, Zhang J, Zennaro MC, Vallo-Boado A, Rodriguez-Soriano J, Furu L, Haws R, Metzger D, Botelho B, Karaviti L, Haqq AM, Corey H, Janssens S, Corvol P, Lifton RP. Autosomal dominant pseudohypoaldosteronism type 1: mechanisms, evidence for neonatal lethality, and phenotypic expression in adults.  J Am Soc Nephrol.  2006 May;17(5):1429-36. (2006) Abstract

Quigley DI, McDonald MT, Krishnamuthy V, Kishnani PS, Lee MM, Haqq AM, Goodman BK. Triploid mosaicism in a 45,X/69,XXY infant. Am J Med Genet A. 2005 Sep 8. (2005) Abstract

Haqq AM, Lien LF, Boan J, Arlotto M, Slentz CA, Muehlbauer MJ, Rochon J, Gallup D, McMahon RL, Bain JR, Stevens R, Millington D, Butler MD, Newgard CB, Svetkey LP. The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design.  Contemp Clin Trials.  2005 Dec;26(6):616-25. (2005) Abstract

Artz E, Haqq A, Freemark M. Hormonal and metabolic consequences of childhood obesity. Endocrinol Metab Clin North Am. 2005 Sep;34(3):643-58. (2005) Abstract

Haqq AM, Stadler DD, Rosenfeld RG, Pratt KL, Weigle DS, Frayo RS, LaFranchi SH, Cummings DE, Purnell JQ. Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader-Willi syndrome.  J Clin Endocrinol Metab.  2003 Aug;88(8):3573-6. (2003) Abstract

Haqq AM, Stadler DD, Jackson RH, Rosenfeld RG, Purnell JQ, LaFranchi SH. Effects of growth hormone on pulmonary function, sleep quality, behavior, cognition, growth velocity, body composition, and resting energy expenditure in Prader-Willi syndrome.  J Clin Endocrinol Metab.  2003 May;88(5):2206-12. (2003) Abstract

Haqq AM, René P, Kishi T, Khong K, Lee CE, Liu H, Friedman JM, Elmquist JK, Cone RD. Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein. Biochem J. 2003 Dec 15;376(Pt 3):595-605. (2003) Abstract

Haqq AM, Farooqi IS, O'Rahilly S, Stadler DD, Rosenfeld RG, Pratt KL, LaFranchi SH, Purnell JQ. Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.  J Clin Endocrinol Metab.  2003 Jan;88(1):174-8. (2003) Abstract

Haqq, AM, Stadler, DD, Rosenfeld, RG, Pratt KL, Weigle, DS, Frayo, RS, LaFranchi, SH, Cummings, DE and Purnell, JQ :  Circulating Ghrelin Levels are Suppressed by Meals and Octreotide Therapy in Children with Prader-willi syndrome (PWS), JCE&M August 2003, in press (2003)

Haqq, AM, Boston, B, and  LaFranchi, S:  Precocious Puberty. Gynecology & Obstetrics, John J. Sciarra, editor, 2003. (2003)

Haqq AM, Farooqi IS, O'Rahilly S, Stadler DD, Rosenfeld RG, Pratt KL, LaFranchi SH, Purnell JQ. Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.  J Clin Endocrinol Metab.  2003 Jan;88(1):174-8. (2003) Abstract

Haqq, AM and Hanna, CE: Precocious puberty caused by an estrogen and androgen secreting adrenal adenoma: A case report and review of the current literature.  The Endocrinologist 11: 9-15, 2001. (2001)

Haqq, AM and Boston, B:    Familial Glucocorticoid Deficiency.  In Emedicine, edited by R. Richman, R.J. Konop, S.F. Kemp, D. Pallares, S. Berger.  www.emedicine.com