Thomas M. Price, MD

Related Content

Locations

• Duke Fertility Center

Services

• Gynecology

Department / Division:
Obstetrics and Gynecology / Reproductive Endocrinology and Fertility

Address:
5704 Fayetteville Road
Durham, NC 27713

Appointment Telephone:
919-572-4673

Office Telephone:
919-572-4673

Fax Telephone:
919-484-0461

• MD, University of North Carolina at Chapel Hill School of Medicine, 1984

• OB/GYN, UNC Hospitals, 1989

• Reproductive Endocrinology, University Texas Southwestern Medical Center, 1991

Clinical Interests:
Assisted reproduction technologies, recurrent pregnancy loss, reproductive tract abnormalities, polycystic ovary syndrome, endometriosis, uterine fibroids

Research Interests:
Dr. Price is involved in both clinical and basic science research.  The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors.  Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion.  Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor.  The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors.  These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

Representative Publications:
Gavrilova-Jordan LP, Price TM. Actions of steroids in mitochondria. Semin Reprod Med. 2007 May;25(3):154-64. (2007) Abstract

Younglai EV, Wu Y, Foster WG, Lobb DK, Price TM. Binding of progesterone to cell surfaces of human granulosa-lutein cells. J Steroid Biochem Mol Biol. 2006 Sep;101(1):61-7. (2006) Abstract

Price TM, Hansen EL, Oliver TN. Immunofluorescent localization of a novel progesterone receptor(s) in a T47D-Y breast cancer cell line lacking genomic progesterone receptor expression. J Soc Gynecol Investig. 2005 Dec;12(8):610-6. (2005) Abstract

Welter BH, Hansen EL, Saner KJ, Wei Y, Price TM. Membrane-bound progesterone receptor expression in human aortic endothelial cells. J Histochem Cytochem. 2003 Aug;51(8):1049-55. (2003) Abstract

Saner KJ, Welter BH, Zhang F, Hansen E, Dupont B, Wei Y, Price TM. Cloning and expression of a novel, truncated, progesterone receptor. Mol Cell Endocrinol. 2003 Feb 28;200(1-2):155-63. (2003) Abstract

Price TM.  Dysfunctional Uterine Bleeding.  In: Rakel RE, Bope ET, (eds) Conn’s Current Therapy.  Philadelphia, Saunders Co.,  pp 1134-6, 2003 (2003)

Price TM, Bates GW.  Adolescent Amenorrhea.  In: Carpenter SEK, Rock JA, (eds).  Pediatric and Adolescent Gynecology (2nd Ed).  Philadelphia, Lippincott Williams and Wilkins, pp., 177-206, 2000 (2000)

Welter BH, Price TM. Magnetic separation to concentrate the estrogen receptor from adipose tissue for western analysis. Biotechniques. 1999 Aug;27(2):282-6. (1999) Abstract

Price TM, O'Brien SN, Welter BH, George R, Anandjiwala J, Kilgore M. Estrogen regulation of adipose tissue lipoprotein lipase--possible mechanism of body fat distribution. Am J Obstet Gynecol. 1998 Jan;178(1 Pt 1):101-7. (1998) Abstract

O'Brien SN, Welter BH, Mantzke KA, Price TM. Identification of progesterone receptor in human subcutaneous adipose tissue. J Clin Endocrinol Metab. 1998 Feb;83(2):509-13. (1998) Abstract

Price TM, Blauer KL, Hansen M, Stanczyk F, Lobo R, Bates GW. Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta-estradiol. Obstet Gynecol. 1997 Mar;89(3):340-5. (1997) Abstract

O'Brien SN, Anandjiwala J, Price TM. Differences in the estrogen content of breast adipose tissue in women by menopausal status and hormone use. Obstet Gynecol. 1997 Aug;90(2):244-8. (1997) Abstract

O'Brien SN, Mantzke KA, Kilgore MW, Price TM. Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue. Anal Quant Cytol Histol. 1996 Apr;18(2):137-43. (1996) Abstract

Price TM, O'Brien SN. Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification. J Clin Endocrinol Metab. 1993 Oct;77(4):1041-5. (1993) Abstract

Price TM, Dupuis RE, Carr BR, Stanczyk FZ, Lobo RA, Droegemueller W. Single- and multiple-dose pharmacokinetics of a low-dose oral contraceptive in women with chronic renal failure undergoing peritoneal dialysis. Am J Obstet Gynecol. 1993 May;168(5):1400-6. (1993) Abstract

Price T, Aitken J, Simpson ER:  Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction (PCR) amplification.  J Clin Endocrinol Metab 74:879-833, 1992 (1992)

Price T, Aitken J, Head J, Mahendroo M, Means G, Simpson ER: Determination of aromatase cytochrome P450 mRNA in human breast tissue by competitive polymerase chain reaction (PCR) amplification.  J Clin Endocrinol Metab. 74:1247-1252, 1992 (1992)