Department / Division:
Medicine / Medical Oncology

Address:
PO Box 2736
Durham, NC 27705

Appointment Telephone:
919-668-6688

Office Telephone:
919-681-1604

Fax Telephone:
919-681-7488

• MD, University at Buffalo SUNY School of Medicine & Biomedical Sciences, 1972

• Internal Medicine, UNC Hospitals, 1972-1974

• Hematology/Oncology, Roswell Park Memorial Institute (New York), 1975-1977

• MPH, Biostatistics, Harvard University (Massachusetts), 1982

Clinical Interests:
Clinical investigation, experimental therapeutics, breast cancer, care of patients with breast cancer with a focus on the management of early-stage patients for staging prognostic evaluation and treatment decision making; extensive experience in providing optimal supportive care to patients receiving systemic chemotherapy

Research Interests:
Design and Analysis of Clinical Trials of Novel Targeted Therapies
Clinical Pharmacology, Pharmacoeconomics and Health Technology Assessment
Research Synthesis and Evidence-Based Oncology
Mathematical and Statistical Risk Modeling and Individualized Medicine
International Health and Healthcare Outcomes in Developing Countries
Clinical and Public Health Decision Making
Environmental and Genetic Epidemiology
Patterns of Care, Disparities and Methods to Improve the Quality of Cancer Care Delivery
Cancer Treatment and Supportive Care in the Elderly

Representative Publications:
von Minckwitz G, Schwenkglenks M, Skacel T, Lyman GH, Pousa AL, Bacon P, Easton V, Aapro MS. Febrile neutropenia and related complications in breast cancer patients receiving pegfilgrastim primary prophylaxis versus current practice neutropaenia management: results from an integrated analysis. Eur J Cancer. 2009 Mar;45(4):608-17. (2009) Abstract

Madeb R, Golijanin D, Noyes K, Fisher S, Stephenson JJ, Long SR, Knopf J, Lyman GH, Messing EM. Treatment of nonmuscle invading bladder cancer: Do physicians in the United States practice evidence based medicine?: the use and economic implications of intravesical chemotherapy after transurethral resection of bladder tumors. Cancer. 2009 Jun 15;115(12):2660-70. (2009) Abstract

Lyman GH. Impact of Chemotherapy Dose Intensity on Cancer Patient Outcomes. J Natl Compr Canc Netw. 2009 Jan;7(1):99-108. (2009) Abstract

Lyman GH. Comparative effectiveness research in oncology: the need for clarity, transparency and vision. Cancer Invest. 2009 Jul;27(6):593-7. (2009) Abstract

Lyman GH, Van Zee KJ, Edge SB: Impact and Remaining Challenges in the Use of Sentinel Node Biopsy in Early-Stage Breast Cancer. ASCO Education Book, 2009; 346-353. (2009)

Lyman GH, Lalla A, Barron RL, Dubois RW. Cost-effectiveness of pegfilgrastim versus filgrastim primary prophylaxis in women with early-stage breast cancer receiving chemotherapy in the united states. Clin Ther. 2009 May;31(5):1092-104. (2009) Abstract

Lyman GH, Kuderer NM, Freedland SJ. Does treatment intensity matter in superficial bladder cancer? Consensus, clinical practice, and confounding. J Natl Cancer Inst. 2009 Apr 15;101(8):543-5. (2009) Abstract

Lyman GH, Khorana AA, Kuderer NM, Lee AY. Cancer and thrombosis: back to the future renewed interest in an old problem. Cancer Invest. 2009 Jun;27(5):472-3. (2009) Abstract

Lyman GH (ed): The Oxford American Handbook of Oncology, Oxford University Press 2009; New York, NY pp 829. (2009)

Lyman G, Lalla A, Barron R, Dubois RW. Cost-effectiveness of pegfilgrastim versus 6-day filgrastim primary prophylaxis in patients with non-Hodgkin's lymphoma receiving CHOP-21 in United States. Curr Med Res Opin. 2009 Feb;25(2):401-11. (2009) Abstract

Khorana AA, Lyman GH: Incidence and Prevention of Cancer-Associated Thrombosis. ASCO Education Book; 2009; 321-325. (2009)

Crawford J, Armitage J, Balducci L, Bennett C, Blayney DW, Cataland SR, Dale DC, Demetri GD, Erba HP, Foran J, Freifeld AG, Goemann M, Heaney ML, Htoy S, Hudock S, Kloth DD, Kuter DJ, Lyman GH, Michaud LB, Miyata SC, Tallman MS, Vadhan-Raj S, Westervelt P, Wong MK. Myeloid growth factors. J Natl Compr Canc Netw. 2009 Jan;7(1):64-83. (2009) Abstract

Balaban EP, Brouwers MC, Lyman GH: Issues in Clinical Practice Guideline Implementation and Utilization. ASCO Education Book, 2009; 338-344. (2009)

Somerfield MR, Einhaus K, Hagerty KL, Brouwers MC, Seidenfeld J, Lyman GH, . American Society of Clinical Oncology clinical practice guidelines: opportunities and challenges. J Clin Oncol. 2008 Aug 20;26(24):4022-6. (2008) Abstract

Lyman GH, Hauser RS. Optimal cancer care across the spectrum of life and disease. Am J Manag Care. 2008 May;14(5):262-4. (2008) Abstract

Lyman GH, Glaspy J: Early Intervention with rhu Erythropoietin for Chemotherapy-Induced Anemia. In Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology – Scientific and Clinical Aspects of Anemia in Cancer, 2nd edition, Springer-Verlag, Wien, New York, 2008: 509-530. (2008)

Lyman GH, Crawford J (eds): Cancer Supportive Care: Advances in Therapeutic Strategies, Informa Healthcare, New York 2008; pp395. (2008)

Khorana AA, Liebman H, White RH, Wun T, Lyman GH: Cancer and Thrombosis 1:The Risk of Venous Thromboembolism in Cancer Patients. ASCO Education Book, 2008: 240-248. (2008)

Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW. Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood. 2008 May 15;111(10):4902-7. (2008) Abstract

Khorana AA, Francis CW, Lyman GH. Reply to frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients. Cancer. 2008 Jul 1;113(1):224. (2008) Abstract

Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai MA, Lyman GH. Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer. Arch Intern Med. 2008 Nov 24;168(21):2377-81. (2008) Abstract

Horan JT, Alonzo TA, Lyman GH, Gerbing RB, Lange BJ, Ravindranath Y, Becton D, Smith FO, Woods WG, . Impact of disease risk on efficacy of matched related bone marrow transplantation for pediatric acute myeloid leukemia: the Children's Oncology Group. J Clin Oncol. 2008 Dec 10;26(35):5797-801. (2008) Abstract

Hanley K, Wang J, Bourne P, Yang Q, Gao AC, Lyman G, Tang P. Lack of expression of androgen receptor may play a critical role in transformation from in situ to invasive basal subtype of high-grade ductal carcinoma of the breast. Hum Pathol. 2008 Mar;39(3):386-92. (2008) Abstract

Greenberg PL, Cosler LE, Ferro SA, Lyman GH. The costs of drugs used to treat myelodysplastic syndromes following national comprehensive cancer network guidelines. J Natl Compr Canc Netw. 2008 Oct;6(9):942-53. (2008) Abstract

Francis CW, Kakkar AK, Levine MN, Lyman GH: Cancer and Thrombosis 2: Prevention of Venous Thromboembolism in Cancer Patients. ASCO Education Book, 2008 250-256. (2008)

Fletcher JW, Djulbegovic B, Soares HP, Siegel BA, Lowe VJ, Lyman GH, Coleman RE, Wahl R, Paschold JC, Avril N, Einhorn LH, Suh WW, Samson D, Delbeke D, Gorman M, Shields AF. Recommendations on the use of 18F-FDG PET in oncology. J Nucl Med. 2008 Mar;49(3):480-508. (2008) Abstract

Ferro SA, Myer BS, Wolff DA, Poniewierski MS, Culakova E, Cosler LE, Scarpace SL, Khorana AA, Lyman GH. Variation in the cost of medications for the treatment of colorectal cancer. Am J Manag Care. 2008 Nov;14(11):717-25. (2008) Abstract

Falanga A, Lee AYY, Streiff MB, Lyman GH: Cancer and Thrombosis 3: Anticoagulation in the Treatment of Venous Thromboembolism in Patients with Cancer. ASCO Education Book, 2008: 258-268. (2008)

Eldar-Lissai A, Cosler LE, Culakova E, Lyman GH. Economic analysis of prophylactic pegfilgrastim in adult cancer patients receiving chemotherapy. Value Health. 2008 Mar-Apr;11(2):172-9. (2008) Abstract

Crawford J, Dale DC, Kuderer NM, Culakova E, Poniewierski MS, Wolff D, Lyman GH. Risk and timing of neutropenic events in adult cancer patients receiving chemotherapy: the results of a prospective nationwide study of oncology practice. J Natl Compr Canc Netw. 2008 Feb;6(2):109-18. (2008) Abstract

Constine LS, Tarbell N, Hudson MM, Schwartz C, Fisher SG, Muhs AG, Basu SK, Kun LE, Ng A, Mauch P, Sandhu A, Culakova E, Lyman G, Mendenhall N. Subsequent Malignancies in Children Treated for Hodgkin's Disease: Associations With Gender and Radiation Dose. Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):24-33. (2008) Abstract

Acharya CR, Hsu DS, Anders CK, Anguiano A, Salter KH, Walters KS, Redman RC, Tuchman SA, Moylan CA, Mukherjee S, Barry WT, Dressman HK, Ginsburg GS, Marcom KP, Garman KS, Lyman GH, Nevins JR, Potti A. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA. 2008 Apr 2;299(13):1574-87. (2008) Abstract

Tang P, Hajdu SI, Lyman GH. Ductal carcinoma in situ: a review of recent advances. Curr Opin Obstet Gynecol. 2007 Feb;19(1):63-7. (2007) Abstract

Shayne M, Culakova E, Poniewierski MS, Wolff D, Dale DC, Crawford J, Lyman GH. Dose intensity and hematologic toxicity in older cancer patients receiving systemic chemotherapy. Cancer. 2007 Oct 1;110(7):1611-20. (2007) Abstract

Pinto L, Liu Z, Doan Q, Bernal M, Dubois R, Lyman G. Comparison of pegfilgrastim with filgrastim on febrile neutropenia, grade IV neutropenia and bone pain: a meta-analysis of randomized controlled trials. Curr Med Res Opin. 2007 Aug 10. (2007) Abstract

Lyman GH, Shayne M. Granulocyte colony-stimulating factors: finding the right indication. Curr Opin Oncol. 2007 Jul;19(4):299-307. (2007) Abstract

Lyman GH, Kuderer NM: Improving outcomes from cancer-associated VTE: lessons from the ASCO guidelines in Cancer Associated Thrombosis, Khorana A, Francis CF, (eds): Informa Healthcare, New York 2007 (2007)

Lyman GH, Kleiner JM. Summary and comparison of myeloid growth factor guidelines in patients receiving cancer chemotherapy. J Natl Compr Canc Netw. 2007 Feb;5(2):217-28. (2007) Abstract

Lyman GH, Khorana AA, Falanga A, Clarke-Pearson D, Flowers C, Jahanzeb M, Kakkar A, Kuderer NM, Levine MN, Liebman H, Mendelson D, Raskob G, Somerfield MR, Thodiyil P, Trent D, Francis CW. American Society of Clinical Oncology Guideline: Recommendations for Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer. J Clin Oncol. 2007 Oct 29. (2007) Abstract

Lyman GH, Cosler LE, Kuderer NM, Hornberger J. Impact of a 21-gene RT-PCR assay on treatment decisions in early-stage breast cancer: an economic analysis based on prognostic and predictive validation studies. Cancer. 2007 Mar 15;109(6):1011-8. (2007) Abstract

Lyman GH, Burstein H (eds): Translational Therapeutic Strategies in Breast Cancer, Informa Healthcare, New York 2007; pp 321. (2007)

Kuderer NM, Khorana AA, Lyman GH, Francis CW. A meta-analysis and systematic review of the efficacy and safety of anticoagulants as cancer treatment: impact on survival and bleeding complications. Cancer. 2007 Sep 1;110(5):1149-61. (2007) Abstract

Kuderer NM, Dale DC, Crawford J, Lyman GH. Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: a systematic review. J Clin Oncol. 2007 Jul 20;25(21):3158-67. (2007) Abstract

Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH. Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy. J Thromb Haemost. 2007 Mar;5(3):632-4. (2007) Abstract

Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH. Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients. Cancer. 2007 Nov 15;110(10):2339-46. (2007) Abstract

Huston A, Lyman GH. Agents under investigation for the treatment and prevention of neutropenia. Expert Opin Investig Drugs. 2007 Nov;16(11):1831-40. (2007) Abstract

Griggs JJ, Culakova E, Sorbero ME, van Ryn M, Poniewierski MS, Wolff DA, Crawford J, Dale DC, Lyman GH. Effect of patient socioeconomic status and body mass index on the quality of breast cancer adjuvant chemotherapy. J Clin Oncol. 2007 Jan 20;25(3):277-84. (2007) Abstract

Griggs JJ, Culakova E, Sorbero ME, Poniewierski MS, Wolff DA, Crawford J, Dale DC, Lyman GH. Social and racial differences in selection of breast cancer adjuvant chemotherapy regimens. J Clin Oncol. 2007 Jun 20;25(18):2522-7. (2007) Abstract

Crawford J, Althaus B, Armitage J, Balducci L, Bennett C, Blayney DW, Cataland SR, Dale DC, Demetri GD, Erba HP, Foran J, Freifeld AG, Heaney ML, Htoy S, Kloth DD, Lyman GH, Messersmith WA, Michaud LB, Miyata SC, Robbins A, Tallman MS, Vadhan-Raj S, Westervelt P, Wong MK, . Myeloid growth factors. Clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2007 Feb;5(2):188-202. (2007) Abstract

Cosler LE, Eldar-Lissai A, Culakova E, Kuderer NM, Dale D, Crawford J, Lyman GH. Therapeutic use of granulocyte colony-stimulating factors for established febrile neutropenia: effect on costs from a hospital perspective. Pharmacoeconomics. 2007;25(4):343-51. (2007) Abstract

Blumberg N, Zhao H, Wang H, Messing S, Heal JM, Lyman GH. The intention-to-treat principle in clinical trials and meta-analyses of leukoreduced blood transfusions in surgical patients.  Transfusion.  2007 Apr;47(4):573-81. (2007) Abstract