Gary H. Lyman, MD, MPH

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• Breast Cancer

Department / Division:
Medicine / Medical Oncology

Address:
DUMC 3645
Durham, NC 27710

Appointment Telephone:
919-668-6688

Office Telephone:
919-681-1604

Fax Telephone:
919-681-7488

• MD, University at Buffalo SUNY School of Medicine & Biomedical Sciences, 1972

• Internal Medicine, UNC Hospitals, 1972-1974

• Hematology/Oncology, Roswell Park Memorial Institute (New York), 1975-1977

• MPH, Biostatistics, Harvard University (Massachusetts), 1982

Clinical Interests:
Clinical investigation, experimental therapeutics, breast cancer, care of patients with breast cancer with a focus on the management of early-stage patients for staging prognostic evaluation and treatment decision making; extensive experience in providing optimal supportive care to patients receiving systemic chemotherapy

Research Interests:
Design and Analysis of Clinical Trials of Novel Targeted Therapies
Clinical Pharmacology, Pharmacoeconomics and Health Technology Assessment
Research Synthesis and Evidence-Based Oncology
Mathematical and Statistical Risk Modeling and Individualized Medicine
International Health and Healthcare Outcomes in Developing Countries
Clinical and Public Health Decision Making
Environmental and Genetic Epidemiology
Patterns of Care, Disparities and Methods to Improve the Quality of Cancer Care Delivery
Cancer Treatment and Supportive Care in the Elderly

Representative Publications:
Somerfield MR, Einhaus K, Hagerty KL, Brouwers MC, Seidenfeld J, Lyman GH, . American Society of Clinical Oncology clinical practice guidelines: opportunities and challenges. J Clin Oncol. 2008 Aug 20;26(24):4022-6. (2008) Abstract

Ramsey SD, Liu Z, Boer R, Sullivan SD, Malin J, Doan QV, Dubois RW, Lyman GH. Cost-Effectiveness of Primary versus Secondary Prophylaxis with Pegfilgrastim in Women with Early-Stage Breast Cancer Receiving Chemotherapy. Value Health. 2008 Jul 31. (2008) Abstract

Lyman GH, Hauser RS. Optimal cancer care across the spectrum of life and disease. Am J Manag Care. 2008 May;14(5):262-4. (2008) Abstract

Lyman GH, Glaspy J: Early Intervention with rhu Erythropoietin for Chemotherapy-Induced Anemia. In Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology – Scientific and Clinical Aspects of Anemia in Cancer, 2nd edition, Springer-Verlag, Wien, New York, 2008: 509-530. (2008)

Lyman GH, Crawford J (eds): Cancer Supportive Care: Advances in Therapeutic Strategies, Informa Healthcare, New York 2008; pp395. (2008)

Khorana AA, Liebman H, White RH, Wun T, Lyman GH: Cancer and Thrombosis 1:The Risk of Venous Thromboembolism in Cancer Patients. 2008 ASCO Education Book, 240-248. (2008)

Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW. Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood. 2008 Jan 23. (2008) Abstract

Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai MA, Lyman GH. Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer. Arch Intern Med. 2008 Nov 24;168(21):2377-81. (2008) Abstract

Horan JT, Alonzo TA, Lyman GH, Gerbing RB, Lange BJ, Ravindranath Y, Becton D, Smith FO, Woods WG. Impact of Disease Risk on Efficacy of Matched Related Bone Marrow Transplantation for Pediatric Acute Myeloid Leukemia: The Children's Oncology Group. J Clin Oncol. 2008 Oct 27. (2008) Abstract

Hanley K, Wang J, Bourne P, Yang Q, Gao AC, Lyman G, Tang P. Lack of expression of androgen receptor may play a critical role in transformation from in situ to invasive basal subtype of high-grade ductal carcinoma of the breast. Hum Pathol. 2008 Jan 8. (2008) Abstract

Greenberg PL, Cosler LE, Ferro SA, Lyman GH. The costs of drugs used to treat myelodysplastic syndromes following national comprehensive cancer network guidelines. J Natl Compr Canc Netw. 2008 Oct;6(9):942-53. (2008) Abstract

Francis CW, Kakkar AK, Levine MN, Lyman GH: Cancer and Thrombosis 2: Prevention of Venous Thromboembolism in Cancer Patients. 2008 ASCO Education Book, 250-256. (2008)

Fletcher JW, Djulbegovic B, Soares HP, Siegel BA, Lowe VJ, Lyman GH, Coleman RE, Wahl R, Paschold JC, Avril N, Einhorn LH, Suh WW, Samson D, Delbeke D, Gorman M, Shields AF. Recommendations on the Use of 18F-FDG PET in Oncology. J Nucl Med. 2008 Feb 20. (2008) Abstract

Ferro SA, Myer BS, Wolff DA, Poniewierski MS, Culakova E, Cosler LE, Scarpace SL, Khorana AA, Lyman GH. Variation in the cost of medications for the treatment of colorectal cancer. Am J Manag Care. 2008 Nov;14(11):717-25. (2008) Abstract

Falanga A, Lee AYY, Streiff MB, Lyman GH: Cancer and Thrombosis 3: Anticoagulation in the Treatment of Venous Thromboembolism in Patients with Cancer. 2008 ASCO Education Book, 258-268. (2008)

Eldar-Lissai A, Cosler LE, Culakova E, Lyman GH. Economic analysis of prophylactic pegfilgrastim in adult cancer patients receiving chemotherapy. Value Health. 2008 Mar-Apr;11(2):172-9. (2008) Abstract

Crawford J, Dale DC, Kuderer NM, Culakova E, Poniewierski MS, Wolff D, Lyman GH. Risk and timing of neutropenic events in adult cancer patients receiving chemotherapy: the results of a prospective nationwide study of oncology practice. J Natl Compr Canc Netw. 2008 Feb;6(2):109-18. (2008) Abstract

Constine LS, Tarbell N, Hudson MM, Schwartz C, Fisher SG, Muhs AG, Basu SK, Kun LE, Ng A, Mauch P, Sandhu A, Culakova E, Lyman G, Mendenhall N. Subsequent Malignancies in Children Treated for Hodgkin's Disease: Associations With Gender and Radiation Dose. Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):24-33. (2008) Abstract

Acharya CR, Hsu DS, Anders CK, Anguiano A, Salter KH, Walters KS, Redman RC, Tuchman SA, Moylan CA, Mukherjee S, Barry WT, Dressman HK, Ginsburg GS, Marcom KP, Garman KS, Lyman GH, Nevins JR, Potti A. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer. JAMA. 2008 Apr 2;299(13):1574-87. (2008) Abstract

Tang P, Hajdu SI, Lyman GH. Ductal carcinoma in situ: a review of recent advances. Curr Opin Obstet Gynecol. 2007 Feb;19(1):63-7. (2007) Abstract

Shayne M, Culakova E, Poniewierski MS, Wolff D, Dale DC, Crawford J, Lyman GH. Dose intensity and hematologic toxicity in older cancer patients receiving systemic chemotherapy. Cancer. 2007 Aug 17. (2007) Abstract

Pinto L, Liu Z, Doan Q, Bernal M, Dubois R, Lyman G. Comparison of pegfilgrastim with filgrastim on febrile neutropenia, grade IV neutropenia and bone pain: a meta-analysis of randomized controlled trials. Curr Med Res Opin. 2007 Aug 10. (2007) Abstract

Lyman GH, Shayne M. Granulocyte colony-stimulating factors: finding the right indication. Curr Opin Oncol. 2007 Jul;19(4):299-307. (2007) Abstract

Lyman GH, Kuderer NM: Improving outcomes from cancer-associated VTE: lessons from the ASCO guidelines in Cancer Associated Thrombosis, Khorana A, Francis CF, (eds): Informa Healthcare, New York 2007 (2007)

Lyman GH, Kleiner JM. Summary and comparison of myeloid growth factor guidelines in patients receiving cancer chemotherapy. J Natl Compr Canc Netw. 2007 Feb;5(2):217-28. (2007) Abstract

Lyman GH, Khorana AA, Falanga A, Clarke-Pearson D, Flowers C, Jahanzeb M, Kakkar A, Kuderer NM, Levine MN, Liebman H, Mendelson D, Raskob G, Somerfield MR, Thodiyil P, Trent D, Francis CW. American Society of Clinical Oncology Guideline: Recommendations for Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer. J Clin Oncol. 2007 Oct 29. (2007) Abstract

Lyman GH, Cosler LE, Kuderer NM, Hornberger J. Impact of a 21-gene RT-PCR assay on treatment decisions in early-stage breast cancer: an economic analysis based on prognostic and predictive validation studies. Cancer. 2007 Mar 15;109(6):1011-8. (2007) Abstract

Lyman GH, Burstein H (eds): Translational Therapeutic Strategies in Breast Cancer, Informa Healthcare, New York 2007; pp 321. (2007)

Kuderer NM, Khorana AA, Lyman GH, Francis CW. A meta-analysis and systematic review of the efficacy and safety of anticoagulants as cancer treatment : impact on survival and bleeding complications. Cancer. 2007 Jul 17. (2007) Abstract

Kuderer NM, Dale DC, Crawford J, Lyman GH. Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: a systematic review. J Clin Oncol. 2007 Jul 20;25(21):3158-67. (2007) Abstract

Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH. Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy. J Thromb Haemost. 2007 Mar;5(3):632-4. (2007) Abstract

Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH. Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy. J Thromb Haemost. 2007 Jan 4. (2007) Abstract

Huston A, Lyman GH. Agents under investigation for the treatment and prevention of neutropenia. Expert Opin Investig Drugs. 2007 Nov;16(11):1831-40. (2007) Abstract

Griggs JJ, Culakova E, Sorbero ME, van Ryn M, Poniewierski MS, Wolff DA, Crawford J, Dale DC, Lyman GH. Effect of patient socioeconomic status and body mass index on the quality of breast cancer adjuvant chemotherapy. J Clin Oncol. 2007 Jan 20;25(3):277-84. (2007) Abstract

Griggs JJ, Culakova E, Sorbero ME, Poniewierski MS, Wolff DA, Crawford J, Dale DC, Lyman GH. Social and racial differences in selection of breast cancer adjuvant chemotherapy regimens. J Clin Oncol. 2007 Jun 20;25(18):2522-7. (2007) Abstract

Crawford J, Althaus B, Armitage J, Balducci L, Bennett C, Blayney DW, Cataland SR, Dale DC, Demetri GD, Erba HP, Foran J, Freifeld AG, Heaney ML, Htoy S, Kloth DD, Lyman GH, Messersmith WA, Michaud LB, Miyata SC, Robbins A, Tallman MS, Vadhan-Raj S, Westervelt P, Wong MK, . Myeloid growth factors. Clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2007 Feb;5(2):188-202. (2007) Abstract

Cosler LE, Eldar-Lissai A, Culakova E, Kuderer NM, Dale D, Crawford J, Lyman GH. Therapeutic use of granulocyte colony-stimulating factors for established febrile neutropenia: effect on costs from a hospital perspective. Pharmacoeconomics. 2007;25(4):343-51. (2007) Abstract

Blumberg N, Zhao H, Wang H, Messing S, Heal JM, Lyman GH. The intention-to-treat principle in clinical trials and meta-analyses of leukoreduced blood transfusions in surgical patients.  Transfusion.  2007 Apr;47(4):573-81. (2007) Abstract

Wittman B, Horan J, Lyman GH. Prophylactic colony-stimulating factors in children receiving myelosuppressive chemotherapy: a meta-analysis of randomized controlled trials. Cancer Treat Rev. 2006 Jun;32(4):289-303. (2006) Abstract

Smith TJ, Khatcheressian J, Lyman GH, Ozer H, Armitage JO, Balducci L, Bennett CL, Cantor SB, Crawford J, Cross SJ, Demetri G, Desch CE, Pizzo PA, Schiffer CA, Schwartzberg L, Somerfield MR, Somlo G, Wade JC, Wade JL, Winn RJ, Wozniak AJ, Wolff AC. 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol. 2006 Jul 1;24(19):3187-205. (2006) Abstract

Shayne M, Crawford J, Dale DC, Culakova E, Lyman GH, . Predictors of reduced dose intensity in patients with early-stage breast cancer receiving adjuvant chemotherapy. Breast Cancer Res Treat. 2006 Dec;100(3):255-62. (2006) Abstract

Lyman GH. Withholding antibiotics from patients with febrile neutropenia. J Clin Oncol. 2006 Mar 1;24(7):1221-2; author reply 1222-3. (2006) Abstract

Lyman GH. Risks and consequences of chemotherapy-induced neutropenia. Clin Cornerstone. 2006;8 Suppl 5:S12-8. (2006) Abstract

Lyman GH. Chemotherapy dose intensity and quality cancer care. Oncology (Williston Park). 2006 Dec;20(14 Suppl 9):16-25. (2006) Abstract

Lyman GH. Benefits of early intervention with erythropoiesis- stimulating proteins in chemotherapy-induced anemia. Oncology (Williston Park). 2006 Jul;20(8 Suppl 6):16-20. (2006) Abstract

Lyman GH, Kuderer NM. Gene expression profile assays as predictors of recurrence-free survival in early-stage breast cancer: a metaanalysis. Clin Breast Cancer. 2006 Dec;7(5):372-9. (2006) Abstract

Lyman GH, Glaspy J. Are there clinical benefits with early erythropoietic intervention for chemotherapy-induced anemia? A systematic review. Cancer. 2006 Jan 1;106(1):223-33. (2006) Abstract

Kuthiala SS, Lyman GH, Ballester OF. Randomized clinical trials for hematopoietic stem cell transplantation: lessons to be learned from the European experience. Bone Marrow Transplant. 2006 Jan;37(2):219-21. (2006) Abstract

Kuderer NM, Dale DC, Crawford J, Cosler LE, Lyman GH. Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. Cancer. 2006 May 15;106(10):2258-66. (2006) Abstract

Komrokji RS, Uppal NP, Khorana AA, Lyman GH, Kaplan KL, Fisher RI, Francis CW. Venous thromboembolism in patients with diffuse large B-cell lymphoma. Leuk Lymphoma. 2006 Jun;47(6):1029-33. (2006) Abstract

Kim T, Giuliano AE, Lyman GH. Lymphatic mapping and sentinel lymph node biopsy in early-stage breast carcinoma: a metaanalysis. Cancer. 2006 Jan 1;106(1):4-16. (2006) Abstract

Khorana AA, Francis CW, Culakova E, Fisher RI, Kuderer NM, Lyman GH. Thromboembolism in hospitalized neutropenic cancer patients. J Clin Oncol. 2006 Jan 20;24(3):484-90. (2006) Abstract

Djulbegovic B, Lyman GH. Screening mammography at 40-49 years: regret or no regret? Lancet. 2006 Dec 9;368(9552):2035-7. (2006) Abstract

Chang S, Long SR, Kutikova L, Bowman L, Crown WH, Lyman GH. Burden of pancreatic cancer and disease progression: economic analysis in the US. Oncology. 2006;70(1):71-80. (2006) Abstract

Aapro MS, Cameron DA, Pettengell R, Bohlius J, Crawford J, Ellis M, Kearney N, Lyman GH, Tjan-Heijnen VC, Walewski J, Weber DC, Zielinski C, . EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours. Eur J Cancer. 2006 Oct;42(15):2433-53. (2006) Abstract