R. Rand Allingham, MD

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Locations

• Duke Eye Center
• Duke Eye Center at Southpoint

Services

• Duke Eye Center

Division Chief

Department / Division:
Ophthalmology / Glaucoma Service

Address:
DUMC 3802
Durham, NC 27710

Appointment Telephone:
(919) 681-3937

Fax Telephone:
(919) 681-8267

• M.D., University of Cincinnati College of Medicine, Ohio, 1979

• Ophthalmology, Eastern Virginia Medical Center, Virginia, 1984-1987

• Glaucoma, Massachusetts Eye and Ear Infirmary, Massachusetts, 1987-1989

Clinical Interests:
Glaucoma (including laser and conventional surgery), cataract surgery with emphasis on combined cataract and glaucoma, and glaucoma implant surgery, research interests include new surgical approaches to glaucoma and the study of genetics in glaucoma and other inherited eye diseases

Research Interests:
My primary research interests for the past six years has been directed at both basic science and clinical research in the subspecialty of glaucoma.  My basic science interests have been functional physiology of the trabecular meshwork in the human eye.  These studies correlated aqueous humor outflow resistence with specific morphologic features of the aqueous humor pathway.  An analysis of tissue in human glaucomatous and normal eyes was performed.  More recently, my major research interest is the study of genetic eye disorders, primarily the inherited glaucomas.   The most common form of glaucoma (primary open-angle glaucoma) is believed to have a strong genetic component.  I am principal investigator for the Duke arm of an NIH funded grant which is directed at identifying the specific gene(s) responsible for this disease.  Over 400 families have been examined to date.  The initiation of the laboratory phase of this investigation has been started.  

In addition to basic science research efforts into the glaucomas, I have an on-going interest in the clinical management of these disorders.  They include 1) examination of various laser treatment modalities in glaucoma; 2) the tissue response to laser surgery; 3) the utilization of mitomycin in glaucoma filtering surgery; and 4) investigations into innovative medical and surgical treatment strategies for glaucoma.

Representative Publications:
Allingham RR, de Kater AW, Ethier CR: Schlemm's canal and primary open angle glaucoma: Correlation between Schlemm's canal dimensions and outflow facility. Experimental Eye Res, 62:101-109, 1996. (1996)

Allingham, R.R.; Williams, P.B., Crouch, E.R., et. al.: Topical applied aminocaproic acid significantly reduces the incidence of secondary hemorrhage in traumatic hyphemia in the rabbit model. Arch Ophthalmol 106:1436-1438, 1988. (1988)

Allingham RR, de Kater AW, Hsu J, Bellows AR: Probe placement and power levels in contact transscleral Nd:YAG cyclophotocoagulation. Arch. Ophthalmol, 108:738-742, 1990. (1990)

Allingham RR, Wiggs JL, Damji KF, Herndon L, Youn J, Tallett DA, Jones KH, Del Bono EA, Reardon M, Haines JL, and Pericak-Vance MA. Adult-onset primary open-angle glaucoma does not localize to chromosome 2cen-q13 in north american families, Hum Heredity 48:251-255, 1998. (1998)