Murat O. Arcasoy, MD

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Services

• Hematology
• Leukemias and Lymphomas

Department / Division:
Medicine / Hematology

Address:
DUMC 3912
Durham, NC 27710

Appointment Telephone:
919-620-4605

Office Telephone:
919-684-5350

Fax Telephone:
919-681-6160

• MD, EGE University Faculty of Medicine (Turkey), 1987

• Internal Medicine, State University of New York, 1988-1991
• Hematology, Yale University School of Medicine (Connecticut), 1992-1995
• Medical Oncology, Yale University School of Medicine (Connecticut), 1997-1998

Clinical Interests:
General hematology, myeloproliferative disorders, myelodysplastic syndromes, hematologic malignancies, anemias, disorders of hemostasis and thrombosis, platelet disorders, sickle cell disease and other hemoglobinopathies

Research Interests:
Dr. Arcasoy's research interests include 1)The role of cytokines and cytokine receptors in hematopoietic commitment and lineage-specific differentiation 2) Mechanisms of tissue-specific expression of erythropoietin receptor (EPOR) gene and its role in lineage commitment and lineage-specific differentiation 3) Studies of the molecular basis of familial and congenital myeloproliferative disorders.4). Isolation of novel hematopoietic cytokine-responsive genes and study of their function and regulation 5). Characterization of novel non-hematopoietic functions of EPOR signaling

Dr. Arcasoy's laboratory has been studying the expression, regulation and function of the EPOR gene focusing on the function of naturally occuring mutations of the EPOR gene that result in primary familial and congenital polycythemia as well as the non-hematopoietic expression and functions of EPOR in vascular endothelium, macrophages, cardiac myocytes and cancer cells. We have also been studying global gene expression in erythroid cells from patients with polycythemia vera to better characterize the molecular signature of the disorder and develop new diagnostic tools.

Representative Publications:
Wang L, Arcasoy MO, Watowich SS, Forget BG. Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells.  Exp Hematol.  2005 Mar;33(3):308-17. (2005) Abstract

Arcasoy MO, Chao NJ. T-cell-mediated pure red-cell aplasia in systemic lupus erythematosus: response to cyclosporin A and mycophenolate mofetil.  Am J Hematol.  2005 Feb;78(2):161-3. (2005) Abstract

Arcasoy MO, Amin K, Vollmer RT, Jiang X, Demark-Wahnefried W, Haroon ZA. Erythropoietin and erythropoietin receptor expression in human prostate cancer.  Mod Pathol.  2005 Mar;18(3):421-30. (2005) Abstract

Arcasoy MO, Amin K, Chou SC, Haroon ZA, Varia M, Raleigh JA. Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia.  Clin Cancer Res.  2005 Jan 1;11(1):20-7. (2005) Abstract

Wright GL, Hanlon P, Amin K, Steenbergen C, Murphy E, Arcasoy MO. Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury.  FASEB J.  2004 Jun;18(9):1031-3. (2004) Abstract

Collins TS, Arcasoy MO. Iron overload due to X-linked sideroblastic anemia in an African American man.  Am J Med.  2004 Apr 1;116(7):501-2. (2004) Abstract

Arcasoy MO, Rockey DC, Heneghan MA. Pure red cell aplasia following pegylated interferon alpha treatment.  Am J Med.  2004 Oct 15;117(8):619-20. (2004) Abstract

Haroon ZA, Amin K, Jiang X, Arcasoy MO. A novel role for erythropoietin during fibrin-induced wound-healing response.  Am J Pathol.  2003 Sep;163(3):993-1000. (2003) Abstract

Arcasoy MO, Jiang X, Haroon ZA. Expression of erythropoietin receptor splice variants in human cancer.  Biochem Biophys Res Commun.  2003 Aug 8;307(4):999-1007. (2003) Abstract

Burns S, Arcasoy MO, Li L, Kurian E, Selander K, Emanuel PD, Harris KW. Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesis. Blood. 2002 Jun 15;99(12):4400-5. (2002) Abstract

Arcasoy MO, Karayal AF, Segal HM, Sinning JG, Forget BG. A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis. Blood. 2002 Apr 15;99(8):3066-9. (2002) Abstract

Arcasoy MO, Maun NA, Perez L, Forget BG, Berliner N. Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression. Eur J Haematol. 2001 Aug;67(2):77-87. (2001) Abstract

Forget BG, Degar BA, Arcasoy MO. Familial polycythemia due to truncations of the erythropoietin receptor.  Trans Am Clin Climatol Assoc.  2000;111:38-44; discussion 44-5. (2000) Abstract

Arcasoy MO, Harris KW, Forget BG. A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. Exp Hematol. 1999 Jan;27(1):63-74. (1999) Abstract

Arcasoy MO, Gallagher PG. Molecular diagnosis of hemoglobinopathies and other red blood cell disorders. Semin Hematol. 1999 Oct;36(4):328-39. (1999) Abstract

Harris KW, Hu XJ, Schultz S, Arcasoy MO, Forget BG, Clare N. The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells. Blood. 1998 Aug 15;92(4):1219-24. (1998) Abstract

Arcasoy MO, Romana M, Fabry ME, Skarpidi E, Nagel RL, Forget BG. High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. Mol Cell Biol. 1997 Apr;17(4):2076-89. (1997) Abstract

Arcasoy MO, Degar BA, Harris KW, Forget BG. Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. Blood. 1997 Jun 15;89(12):4628-35. (1997) Abstract

Arcasoy MO, Gallagher PG. Hematologic disorders and nonimmune hydrops fetalis. Semin Perinatol. 1995 Dec;19(6):502-15. (1995) Abstract

Mookerjee B, Arcasoy MO, Atweh GF. Spontaneous delta- to beta-globin switching in K562 human leukemia cells. Blood. 1992 Feb 1;79(3):820-5. (1992) Abstract

Luo XN, Arcasoy MO, Brickner HE, Mistry S, Schechter AD, Atweh GF. Regulated expression of p18, a major phosphoprotein of leukemic cells. J Biol Chem. 1991 Nov 5;266(31):21004-10. (1991) Abstract