Department / Division:
Pediatrics / Nephrology

Address:
DUMC 3959
Durham, NC 27710

Appointment Telephone:
919-668-4000

Office Telephone:
919-684-4246

Fax Telephone:
919-684-6616

• MD, Emory University School of Medicine (Georgia), 1979

• MD Anderson Cancer Center & University of Texas Medical School, Houston, 1979-1982

• University of California Los Angeles, 1984-1987

Clinical Interests:
Collagen-vascular diseases, autoimmune glomerular disease, hematuria, proteinuria, dialysis, renal transplantation, hypertension

Research Interests:
My interests are in the diagnosis and treatment of secondary and inflammatory renal diseases, hypertension and general nephrology.  I have been involved specifically in the treatment of childhood hypertension, infections, glomerulonephritis, and secondary disease related to human immunodeficiency virus, sickle cell anemia, and systemic lupus erythematosus.  My previous basic training is in the area of complement mediated injury, immune cell aberrancies, and transplant rejection.

Representative Publications:
Fitzhugh CD, Wigfall DR, Ware RE. Enalapril and hydroxyurea therapy for children with sickle nephropathy.  Pediatr Blood Cancer.  2005 Dec;45(7):982-5. (2005) Abstract

Bruno D, Wigfall DR, Zimmerman SA, Rosoff PM, Wiener JS. Genitourinary complications of sickle cell disease.  J Urol.  2001 Sep;166(3):803-11. (2001) Abstract

Wigfall DR, Ware RE, Burchinal MR, Kinney TR, Foreman JW. Prevalence and clinical correlates of glomerulopathy in children with sickle cell disease.  J Pediatr.  2000 Jun;136(6):749-53. (2000) Abstract

Wigfall DR, Frank MM, Khan W: Complement and kinins: Mediators of Inflammation. Clinical Diagnosis and Management by Laboratory Methods, 19th edition. John Bernard Henry (ed), 1995 (1995)

Wigfall DR, Saadi S, Ihrcke NS, Lindman BJ, Frank MM, Platt JL. Non-Cytotoxic Mechanisms of Complement Mediated Vascular Disease. Journal of the American Society of Nephrology, Vol. 4 (3): 642a, 1993. (1993)