Vinod K. Prasad, MD, MRCP

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• Pediatric Blood and Marrow Transplant

Department / Division:
Pediatrics / Blood and Marrow Transplantation

Address:
DUMC 3350
Durham, NC 27710

Appointment Telephone:
919-668-1100

Office Telephone:
919-668-0442

Fax Telephone:
919-668-1180

• MB BS (1983), MD (Pediatrics, 1986) - University of Delhi, India
• University of Delhi Pediatrics Training, India, 1984-1989

• Member of Royal College of Physicians (MRCP), London, 1990
• Pediatric Hematology Oncology, Hammersmith Hospital and Hospital for Sick Children, London; and St. James' University Hospital, Leeds, 1990-1993

• Fellowship, Memorial Sloan Kettering Cancer Center and Cornell University Medical Center, New York, 1994-1997

Clinical Interests:
Cord blood, stem cell, and bone marrow transplant for childhood cancers, inherited metabolic disorders, immunodeficiency, Hemoglobinopathies and other serious diseases; lab research in histocompatibility (tissue typing) and other determinants of alloreactivity with a focus on identifying the best matched donor by cutting edge molecular techniques; clinical research in post-transplant viral infections with a focus on early detection and treatment

Research Interests:
1. Expanding the role of umbilical cord blood transplants for inherited metabolic disorders.
2. Clinical Studies and analyses to correlate various components of histocompatibility and other determinants of alloreactivity and their impact on unrelated cord blood transplant outcomes.
3. Studies to analyse the impact of Killer Immunoglobulin receptors on the outcomes of hematopoietic stem cell transplantation utilizing haploidentical, CD34 selected, familial grafts.
4. Propective longitudinal study of serial monitoring of adenovirus in allogenic transpants(SMAART)patients.
5. Use of mesenchymal stem cells for the treatment of GVHD

Representative Publications:
Prasad VK, Mendizabal A, Parikh SH, Szabolcs P, Driscoll TA, Page K, Lakshminarayanan S, Allison J, Wood S, Semmel D, Escolar ML, Martin PL, Carter S, Kurtzberg J. Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplant outcomes. Blood. 2008 Jun 27. (2008) Abstract

Prasad VK, Kurtzberg J. Emerging trends in transplantation of inherited metabolic diseases. Bone Marrow Transplant. 2008 Jan;41(2):99-108. (2008) Abstract

Prasad VK, Chen D-F, Broadwater G, Reinsmoen NL, Clark A, Chao NJ, and Rizzieri DA: Impact of Inhibitory and Activating KIR and HLA Ligands in Non-Myeloablative Haplo Hematopoietic Transplants in Patients with High-Risk Lymphoid Malignancy. 15th International Histocompatibility and Immunogenetics Workshop and Conference, 2008. (2008)

Hollingsworth C, Frush D, Kurtzberg J, and Prasad VK: Role of Imaging in Pediatric Hematopoietic Stem Cell Transplantation. Radiology, August 2008: 248; 348-365 (2008)

Prasad VK, Lucas KG, Kleiner GI, Talano JM, Jacobsohn D, Szabolcs P, Monroy R, and Kurtzberg J. Use of Mesenchymal Stem Cells to Treat Pediatric Patients with Severe (Grade III-IV) acute Graft versus Host Disease refractory to steroid and other agents on a Compassionate Use Basis. American Society of Hematology Annual meeting, 2007 (2007)

1. Ten Allele High-Resolution DNA Typing has a Direct Impact on the Disease Free Survival (DFS) In Pediatric Recipients of T-cell depleted (TCD) Unrelated Donor (URD) Hematopoietic Stem Cell Transplant (HCT). VK Prasad, A. Selvakumar, H Dastigir, F. Boulad, S Prockop,  T.N. Small,  R.J. O'Reilly B. Dupont, NA Kernan. Presented at American Society of Bone Marrow Transplantation annual meeting at Orlando, 2004; Biology of Blood & Marrow Transplantation, 2004 Vol 10(2) supp1:abstr #146.
(2004)

Seo SK, Regan A, Cihlar T, Lin DC, Boulad F, George D, Prasad VK, Kiehn TE, Polsky B. Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance. Clin Infect Dis. 2001 Nov 1;33(9):e105-8. (2001) Abstract

Prasad VK, Kernan NA, Heller G, O'Reilly RJ, Yang SY. HLA-C disparity between patients and unrelated donors matched for HLA-A, -B, and -DRB1 alleles: impact of serological vs. DNA typing for HLA-A and -B loci. Biol Blood Marrow Transplant. 1999;5(2):77-85. (1999) Abstract

Prasad VK, Kernan NA, Heller G, O'Reilly RJ, Yang SY. DNA typing for HLA-A and HLA-B identifies disparities between patients and unrelated donors matched by HLA-A and HLA-B serology and HLA-DRB1. Blood. 1999 Jan 1;93(1):399-409. (1999) Abstract

Prasad VK, Heller G, Kernan NA, O'Reilly RJ, Yang SY. The probability of HLA-C matching between patient and unrelated donor at the molecular level: estimations based on the linkage disequilibrium between DNA typed HLA-B and HLA-C alleles. Transplantation. 1999 Oct 15;68(7):1044-50. (1999) Abstract

Prasad VK, Yang SY. Allele assignment for HLA-A, -B, and -C genes to the Tenth International Histocompatibility Workshop cell lines. Tissue Antigens. 1996 Jun;47(6):538-46. (1996) Abstract

Prasad VK, Lewis IJ, Aparicio SR, Heney D, Hale JP, Bailey CC, Kinsey SE. Progressive glomerular toxicity of ifosfamide in children. Med Pediatr Oncol. 1996 Sep;27(3):149-55. (1996) Abstract

Prasad VK, Kim IK, Farrington K, Bussel JB. TTP following ITP in an HIV-positive boy. J Pediatr Hematol Oncol. 1996 Nov;18(4):384-6. (1996) Abstract

Prasad VK, Aronson DC, Gerald WL, Meyers PA, La Quaglia MP. Hepatic focal nodular hyperplasia in infant antenatally exposed to steroids. Lancet. 1995 Aug 5;346(8971):371. (1995) Abstract

McClure RJ, Prasad VK, Brocklebank JT. Treatment of hyperkalaemia using intravenous and nebulised salbutamol. Arch Dis Child. 1994 Feb;70(2):126-8. (1994) Abstract