The purpose of this study is to evaluate the effects of different amounts and intensities of aerobic exercise, when compared to the combination of an aerobic exercise plus diet lifestyle intervention, on measures of glucose control in sedentary, overweight adults with pre-diabetes.

Eligibility Requirements

Participants must:

• Be between 45 and 75 years old
• Have a body mass index > 25.0 - < 35.4 kg/m2
• Have fasting glucose > 95 - < 125 mg/dL
• Exercise less than one day per week

Participants must not:

• Smoke
• Be dieting
• Have any prior diagnosis of diabetes or heart disease
• Be pregnant or intend to become pregnant
• Have any allergy to xylocaine (numbing medicine)
• Be taking confounding medications
• Have a history of hypertension
• Be unwilling to exercise at least twice per week at the Duke Center for Living Health and Fitness Center during research study staff supervised times

For more information, contact Leslie Kelly at 919-681-9000 or leslie.kelly@duke.edu.