The purpose of this study is to provide additional information about a medical device intended to help treat high blood pressure in research participants whose blood pressure is not controlled, despite treatment with multiple blood pressure medications.

Participants are considered for this study after their doctor determines that their blood pressure is not controlled with medications.

In addition to current blood pressure medications, participants may undergo a procedure using a medical device that delivers low-level radiofrequency (RF) energy through the wall of the blood vessel to the kidney (renal artery) to disrupt the nerves that lead to the kidney.

Eligibility Requirements

To be eligible to participate in this trial, participants must meet the following requirements:

• Be between the ages of 18 and 80 years old at the time of randomization
• Receive a stable medication regimen including full, tolerated doses of three or more anti-hypertensive medications of different classes, of which one must be a diuretic (with no changes for a minimum of two weeks prior to screening) that is expected to be maintained without changes for at least six months
• Have a  systolic blood pressure (SBP) of ≥ 160 mmHg based on an average of three blood pressure readings measured at both an initial screening visit and a confirmatory screening visit
• Agree to have all study procedures performed, and is competent and willing to provide written, informed consent to participate in this clinical study

For more information, contact Heart Communication Center at 919-681-5816. Select option #2 or #3.