The purpose of this study is to test two quit smoking therapies and to study brain function while each therapy is being used. You will be randomly assigned (like flipping a coin) to one of the two groups. The first therapy is Extinction-Based therapy (EBT). If you are in this group, you will switch to smoking denicotinized cigarettes while wearing a 21 mg/d nicotine patch for one month prior to your quit date. The second therapy is a standard Nicotine Replacement therapy (NRT). If you are in this group, you will smoke your usual brand of cigarettes up to the quit date. Following the quit date, both groups will undergo standard nicotine replacement therapy (21 mg/d for 6 weeks; 14 mg/d for 2 weeks, 7 mg/d for 2 weeks).

Eligibility Requirements:

• Age 18 to 55
• Cigarette smoker
• An interest in quitting smoking

Study Requirements:

• One screening session with physical exam
• One functional magnetic resonance imaging (fMRI) training session
• Three fMRI scanning sessions
• Seven lab sessions
• Two follow-up sessions

Compensation: Up to $810

For more information, call 919-684-9593, email smokingresearch@dm.duke.edu, or visit our website http://dukesmokingresearch.wordpress.com.