Cognitive impairment occurs frequently in seniors and older adults undergoing cardiac operations.

Post-operative cognitive decline (impairment in memory, attention, and thinking) is present in over one third of patients at six weeks after surgery and persists in a larger number of patients up to five years after surgery. This decline in cognitive function leads to a reduction in quality of life for both the patient and the patient’s family.

The primary purpose of this study is to determine the frequency and nature of brain changes associated with cognitive decline in patients undergoing cardiac surgery. Brain changes will be detected by magnetic resonance imaging (MRI) and tests of attention, memory, and concentration.

A total of 55 subjects 50 years old or older will be enrolled in this research protocol -- 29 undergoing cardiac surgery and 26 with cardiovascular disease not requiring surgery.

Subjects will be compensated a total of $171 to cover time and expenses. Participation requires three three-hour study visits; one at baseline, one at six weeks and another one year after baseline.

For more information, contact Roger Hall at 919-681-2978.