Purpose

Eligibility

To participate in this study, you must be at least 18 years old and have:

• Histologically confirmed diagnosis of advanced or metastatic gastric carcinoma or adenocarcinoma of the gastroesophageal junction
• Measurable disease and an ECOG performance status of </= 2
• Adequate bone marrow reserve, hepatic, renal, and cardiovascular function

Exclusion Criteria

You will not be included in the study if you are pregnant or breastfeeding, HIV positive, or have brain metastases or any uncontrolled intercurrent illness.  

You will also be exluded if you have received:

• Rradiation to >/=25 percent of bone marrow within 14 days of GSK1363089
• More than two prior anti-cancer therapies
• Prior treatment with a c-met inhibitor or antibodies against HGF

For more information, contact the clinical research coordinator at 919-668-1861.