The purpose of this study is to evaluate the safety and efficacy of the Medtronic CoreValve System in the treatment of symptomatic severe aortic stenosis in research participants who are at high risk for aortic valve surgery.
High-risk surgical research participants will be randomized to receive either transcatheter aortic valve implant (TAVI) with the Medtronic CoreValve System (MCS) or standard aortic valve replacement surgery.
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