This is a two-day study investigating metabolism in subjects with non-alcoholic fatty liver disease (NAFLD) in comparison to subjects without liver disease and subjects with other forms of liver disease.

Screening for diabetes and insulin resistance is performed on day one. If the subject has a normal result, then we will proceed to day two, which includes an IV glucose tolerance test.

Subjects will not receive compensation for taking part in this study.

Eligibility

Inclusion Criteria

Subjects will be considered based on:

• Appropriate screening history
• Physical examination
• Laboratory, radiologic, and histologic review of medical evaluation to confirm or negate the presence or absence of NAFLD and/or the presence of non-steatosis hepatitis

Exclusion Criteria

• Less than 20 grams of alcohol consumption per day
• Impaired oral glucose tolerance test
• Known diagnosis of diabetes mellitus
• Hepatitis C infection
• Cirrhosis infection

For more information, contact Dawn Piercy at 919-684-0129.