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A Study Comparing Measures of Ventilatory Heterogeneity (VH) in Asthma Patients
This is a 3-period, non-randomized study in patients with either mild asthma (exercise induced or currently maintained on Step I / II medications [NAEPP guidelines]) or moderate/severe asthma (NAEPP clinical profile with Step III-IV medication use) and a history of clinical exacerbations to evaluate Oe 1H- and 19F-MRI as treatment response biomarkers in future clinical trials. This study will also assess the reproducibility of both MRI measurements to determine their utility as enhanced functional pulmonary biomarkers, and a window into their predictive value for exacerbations will be obtained through the use of a post-study clinical review at 6 months following study completion (REF# 38169)
Hyperpolarized 129Xe MR Imaging of Pulmonary Function in Healthy Volunteers and Subjects with Pulmonary Disease
Duke University Medical Center is recruiting healthy subjects over age 50 to participate in a magnetic resonance imaging (MRI) study of lung function.