Clinical Trials

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Ixmyelocel-T Study
Intramuscular injections of autologous Ixmyelocel-T cells versus placebo for the treatment of patients with peripheral artery disease and critical limb ischemia with no options for revascularization. (REF# Pro00040839)

A Phase II, Randomized, Double-Blind, Multicenter, Multinational, Placebo-Controlled, Parallel-Groups Study to Evaluate the Safety and Efficacy of Intramuscular Injections of Allogeneic PLX-PAD Cells for the Treatment of Subjects with Intermittent Claudication (IC)
Intramuscular injection of placental (PLX-PAD) cells versus placebo for the treatment of patients with peripheral artery disease and intermittent claudication. (REF# Pro00038962)

EUCLID – Examining Use of Ticagrelor in PAD
Determine the efficacy and safety of oral antiplatelet agents (ticagrelor versus clopidogrel) in patients with symptomatic peripheral artery disease (prior revascularization procedure or ABI < 0.80). (REF# Pro00039981)

Dietary Nitrate to Augment Exercise Training Benefits in DM+PAD
We are seeking approximately 28 people (ages 40-80) with peripheral arterial disease and type II diabetes. This study is based at the Non-Invasive Vascular Laboratory at the Duke Center for Living campus. (REF# Pro00039608)

Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PAD
The purpose of this study is to determine if regular consumption of a high nitrate supplement in conjunction with 12 weeks of supervised exercise training will produce a greater benefit in blood vessel function, muscle function and physical performance than 12 weeks of exercise alone. (REF# 00031918)

EXSCEL
Patients with poorly controlled blood sugars are needed for a study to examine the effects of exenatide on type 2 diabetes and cardiovascular disease. (REF# 25038)