Clinical Trials

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Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers
This study consists of a physical screening session (scheduled between 8:00 am and 2:30 pm Monday through Friday) and seven study visits over a 13-week period. You may also be asked to come in for a follow-up visit six months after your quit day. Your entire participation, including six-month follow-up, will last approximately seven months.
The physical screening visit will take approximately 2 to 2 ½ hours, and includes a physical exam and a drug screening test. If you test positive for illegal drugs, you will not be eligible to participate. (REF# 00042699)

Human Lung regional Ventilation Defect Severity measured by Fluorine-19 Gas MRI
An open label study in 250 subjects over five years. We are planning 130 subjects with COPD (varies stages of GOLD I-IV) and 120 normal subjects (non-smokers, ex smokers and current smokers with normal PFT’s). (REF# 37791)

Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments (CameraCue)
FIXME (REF# Pro00033975)

Emotion Dysregulation in ADHD and non-ADHD smokers
The purpose of this study is to examine the association between emotion dysregulation and smoking cigarette smoking in attention deficit and hyperactivity disorder (ADHD) smokers and non-ADHD smokers. (REF# Pro00034996)

Live for Life Smoking Cessation Study -- Duke Employees Only
The purpose of this study is to investigate the potential relationship between genes you have inherited and your response to treatment to help you quit smoking cigarettes. It will also be used to determine the potential cost-effectiveness of the treatments used for smoking cessation. (REF# 32605)

Nicotine Patch Pretreatment for Smoking Cessation in PTSD
You may be eligible to participate in a research study testing an experimental way to help people quit smoking. (REF# 5550)

Ovarian Hormones and Smoking
The Duke ADHD Program is looking for control female smokers for a study researching connections between female hormones and smoking. (REF# 27995)

Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation
The purpose of this study is to look at brain function and attempt to predict which study drug or combination (nicotine patches, Chantix alone, or Chantix paired with Zyban) will be successful in helping individual smokers quit smoking. (REF# 28331)

Long Term Oxygen Treatment Trial (LOTT)
The purpose of this trial is to examine whether oxygen therapy prolongs and improves the quality of life in those patients who have moderately reduced oxygen levels or those who use oxygen with exercise or sleep. (REF# 13060)

Neurobiology of Response Inhibition in Comorbid ADHD and Nicotine Dependence
This study seeks adult smokers with and without ADHD. (REF# 9085)

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