Clinical Trials

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Smoking Asthmatics Research Study
Asthma patients who also smoke are needed to take part in a research study at the Duke Clinical Research Unit. The study will examine whether questionnaires used to evaluate asthma symptoms in non-smokers can also be applied to people with asthma who smoke. Participation will require 2 clinic visits that are approximately 6 weeks apart. (REF# 41549)

Human Lung regional Ventilation Defect Severity measured by Fluorine-19 Gas MRI
An open label study in 250 subjects over five years. We are planning 130 subjects with COPD (varies stages of GOLD I-IV) and 120 normal subjects (non-smokers, ex smokers and current smokers with normal PFT’s). (REF# 37791)

Asthma Patient Registry
The Duke Clinical Research Unit is enrolling people with asthma into the American Lung Association's Asthma Clinical Research Center patient registry. (REF# 18719)

Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients with Asthma
Asthma patients who do not smoke and have been using medication for at least a year are needed to take part in a research study at the Duke Clinical Research Unit. (REF# 34572)

Safety and Efficacy of a Lysophosphatidic Acid Receptor Antagonist in Idiopathic Pulmonary Fibrosis
To evaluate the safety and tolerability of treatment with an investigational drug versus a placebo in volunteers with a diagnosis of IPF. (REF# 41242)

Bronchial Thermoplasty in Severe Persistant Asthma
FIXME (REF# 00028329)

Screening Tests for Susceptibility to Immersion Pulmonary Edema
Healthy volunteers are needed for a research study of the effect of exercise while immersed to the neck in water on cardiac (heart) function. (REF# 19996)

Long-Acting Beta Agonist Step Down Study (LASST)
Males and females, age 12 years and older are needed to participate in a research study to evaluate the optimal treatment strategy for reducing therapy in people with asthma. (REF# Pro00034544)

Trial of a Monoclonal Antibody to CD20 (rituximab) for the Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Patients with pulmonary arterial hypertension (PAH) are needed to participate in a study examining the effectiveness of rituximab. (REF# 26635)

Combination Bosentan/Sildenafil Versus Sildenafil Monotherapy in Patients with Pulmonary Arterial Hypertension
This trial examines the effects of combination of bosentan and sildenafil versus sildenafil monotherapy on morbidity and mortality in symptomatic patients with pulmonary arterial hypertension. (REF# 8325)

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