Study Purpose

A group of essential amino acids, known as Branched-chain amino acids (BCAA) are known to be associated with blood sugar regulation and insulin resistance.  The purpose of this study is to investigate how the Branched-chain Amino Acids contribute to insulin resistance in overweight and obese individuals and their source in the plasma.

Eligibility Requirements

We are seeking 30 people between the ages of 40 – 65.   Participants will be divided into three groups: Lean Control Group; Pre-Diabetic Exercise Group; and a Gastric Bypass Surgery Group.

*PD group must be exercising less than one day per week

All participants will be asked to take part in several clinical testing visits including a Glucose Screening, Oral Glucose Tolerance Test, Treadmill Test (PD group only), Body Composition, Resting Metabolic Rate, Insulin Resistance Testing and Branched-Chain Amino Acid Testing.

• Lean Group – will be asked to take part in several clinical testing visits.
• PD Group – will receive 6-months of Aerobic and Resistance exercise training at the Duke Center For Living.
• GBP Group – will be asked to take part in several testing visits prior to, and 3-months after, their elective gastric bypass surgery.

Compensation

Participants will receive $450 - $1050 upon completion of the study based on the specified group testing requirements.

For more information, contact Lucy Piner at 919-660-6781 or lucy.piner@duke.edu.