We will test whether the DASH diet lowers blood pressure in adults who have both high blood pressure and kidney disease. DASH stands for Dietary Approaches to Stop Hypertension. This diet is rich in fruits, vegetables, low-fat dairy products, whole grains, and lean meats, but low in saturated fat and cholesterol. The DASH diet is known to lower blood pressure in people with normal kidney function, but we do not know if it lowers blood pressure in people with reduced kidney function, or if it is safely tolerated.
We seek to enroll 10-20 people, 18 years of age or older, with a systolic blood pressure (top number) of 140-179 mmHg OR a diastolic blood pressure (bottom number) of 90-110 mmHg, and Stage 3 chronic kidney disease (glomerular filtration rate of 30-59 ml/min/m2).
WHAT IS INVOLVED IN THE STUDY?
We will provide you with a study diet for 3 weeks and:
• Ask that you eat either lunch or dinner at the study center, 5 days per week (Monday-Friday), during the 3 week study period.
• Ask that you eat only the food we provide for you.
• Ask you to fill out a daily food questionnaire.
• Measure your weight daily and adjust the amount of calories we give you to keep your weight from changing.
• Measure your blood pressure every week for 3 weeks.
• Collect samples of your blood and urine once per week for 3 weeks.
• Reimburse you for your time and travel to the weekday study visits.
This study will last 3 weeks. However, you will need to attend 2-3 short screening visits before the study starts to determine if you are eligible to participate.
You will be reimbursed up to $225 ($15 per weekday visit during the 3 week study period) for expenses related to your participation (travel and time). You will also receive all of your meals and snacks during the study period.
For more information, contact: Crystal Tyson MD - (919) 660-6671, or Aziza Sutton - (919) 681-2489
For more information, contact Crystal Tyson at 9196606671.