The main purpose of the NNSG study is to evaluate the effects of nicotine exposure in a group of nonsmoking young adults with and without ADHD. This research question is being assessed amongst a population of non-smokers, who have never smoked an entire cigarette during their lifetime and not used other tobacco products for at least 3 years. During the study, participants will be given a small amount of nicotine or placebo, in a spray form, and then asked to perform tasks and answer questionnaires. A secondary purpose is to research how genetics may be related to why some people, particularly with ADHD, will begin smoking or use other products containing nicotine, while others will not.

The NNSG Study is recruiting adults without ADHD (Controls), and with ADHD or those that experience the following difficulties:

• Having trouble paying attention
• Making careless mistakes
• Difficulty completing work
• Disorganization
• Forgetfulness
• Restlessness
• Impatience

Between the ages of 18 and 25
Pregnant women are not allowed to participate

Subjects don't need a previous diagnosis of ADHD to participate.

Study Requirements

The study involves:
• Screening Visit (~ 5 hours)
• 3 Experimental Sessions (~ 4.5 hours each)
• 2 Sampling Sessions (~ 5.5 hours each)
• 1 month follow-up phone call
• Blood draws for genetics, assessing nicotine, and pregnancy testing.

The study involves the use of both nicotine nasal and placebo nasal sprays.

Compensation

• Compensation is up to $600.
• ADHD subjects successfully screened can request an ADHD evaluation report.

For more information, contact Joseph English at 919.681.0028.