Dr. Richard Bedlack is conducting a research study of an investigational new drug for pseudobulbar affect (PBA), a condition characterized by involuntary and inappropriate outbursts of laughing and/or crying. The outbursts can occur spontaneously or in response to circumstances such as watching a movie.

The purpose of this research study is to determine if AVP-923, an investigational drug, is safe, and to see if it helps in controlling symptoms of PBA in subjects with ALS or MS, when compared to placebo.

The study will consist of four scheduled visits. Study drug will be taken twice a day for 12 weeks.

Subjects must be between 18 and 80 years of age.

Subjects will be reimbursed $50 for each completed visit related to travel expenses.

For more information, contact Karen Grace at 919-668-2844.