Blocking the Critical Structure that Lets Cancer Cells Move -- Their Feet (DukeHealth.org)
Dec. 16, 2010
Scientists now know that some cancer cells spread, or metastasize, throughout the body the old-fashioned way -- by using their feet. But researchers at Duke Cancer Institute have discovered a way to short-circuit their travels by preventing the development of these feet, called invadopodia. This discovery is even more important because blocking these "feet" also blocks proteins in the feet that burn through intact tissue and let cancer cells enter new cells.
Scientists Decode Secrets of a Very Common Virus that Can Cause Cancer (DukeHealth.org)
Dec. 16, 2010
About 90 percent of people are infected at some time in their lives with Epstein-Barr virus (EBV), usually with no ill effects. But individuals with compromised immune systems, such as people with organ transplants or HIV infection, have a greater risk of cancer occurring because of this virus.
Ovarian Cancer Advances When Genes Are Silenced (DukeHealth.org)
Dec. 13, 2010
There are many mechanisms that alter the activity of genes -- direct changes to the DNA code like mutations and deletions, or changes that control when genes are switched on and off, called epigenetic means. Tumor-suppressor genes are often inactivated through epigenetics, which provides an opening for the cancerous growth of cells.
Biological Diversity of Ovarian Cancer Lessens Value of Screening (DukeHealth.org)
Dec. 13, 2010
Cancer prevention experts have long been frustrated by the lack of a meaningful way to screen women for ovarian cancer. It is a relatively rare disease that often progresses with few symptoms until it is too late for potentially curative treatments, and elevated values of the most commonly used biomarker used in screening, CA125, are also related to other disorders.
Two Studies Find New Genetic Links to Ovarian Cancer Risk (DukeHealth.org)
Sept. 19, 2010
An international consortium of scientists has discovered new genetic variants in five regions of the genome that affect the risk of ovarian cancer in the general population, according to two separate studies published online in Nature Genetics.
National Cancer Institute Renews Duke Comprehensive Cancer Center Core Grant (DukeHealth.org)
Sept. 14, 2010
The Duke Comprehensive Cancer Center (DCCC) has received a 5-year, $30 million core grant renewal from the National Cancer Institute (NCI) to support its broad range of clinical, research, and educational programs designed to lessen the impact of cancer upon the lives of people throughout North Carolina and beyond.
Alphavirus-Based Vaccine May Slow Some Cancers (DukeHealth.org)
Aug. 2, 2010
An experimental vaccine based on a virus that causes encephalitis in the wild appears to block tumor growth in some cases of advanced cancer, according to researchers at Duke University Medical Center.