R. Edward Coleman, MD

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Services

• General and Consultative Heart Care
• Radiology

Director

Department / Division:
Radiology / Nuclear Medicine

Address:
DUMC 3949
Durham, NC 27710

Appointment Telephone:
919-684-7245

Office Telephone:
919-684-7244

Fax Telephone:
919-684-7135

• MD, Washington University, 1968

• Medicine, Royal Victoria Hospital, 1970
• Nuclear Medicine, Mallinckrodt Institute of Radiology, 1972-1974

Clinical Interests:
General nuclear medicine, positron emission tomography, radionuclide therapy

Research Interests:
Tumor characterization by radionuclide imaging techniques is the general theme of the research.  The methods of imaging include the use of planar gamma cameras, single photon emission computed tomography (SPECT) and positron emission tomography (PET).  The radiopharmaceuticals that are used include FDA-approved agents, IND agents (monoclonal antibodies for diagnosis and therapy, I-131 MIBG for therapy of neuroendocrine tumors), Radioactive Drug Research Committee approved agents (0-15 water for tumor blood flow, F-18 labeled agents for PET imaging of tumors etc.), and F-18 fluorodexoyglucose for the study of metabolism.  The research projects include the quantification of pulmonary perfusion by SPECT imaging of patients with pulmonary cancer before and after radiation therapy, determination of kinetics and radiation dosimetry of radionuclide labeled monoclonal antibodies administered for therapeutic purposes, radionuclide therapy of neuroendocrine tumors, the metabolic characterization of brain tumors before and after therapy, and development of new methods for characterizing neuroendocrine tumors.  The effects of chemotherapy, radiation therapy, and surgery on tumor and normal tissue metabolism are being studied using PET.  Methods for improving the quantitative integrity of the information provided from the radiopharmaceuticals that are administered are being developed in the SPECT and PET laboratories.  This research bridges the basic science developments and the clinical expertise in imaging.

Representative Publications:
Keogan MT, Tyler D, Clark L, Branch MS McDermott VG, Delong DM, Coleman RE: diagnosis of pancreatic carcinoma: Role of FDG PET AJR 171:1565-1570, 1998. (1998)

Coleman RE: Clinical PET in oncology. Clinical Positron Imaging 1:15-30, 1998. (1998)

Al-Sugair A, Coleman RE: Applications of PET in lung cancer. Semin Nucl Med 28 (4):303-319, 1998. (1998)

Ahuja V, Coleman RE, Herdon J, Patz EF Jr: Prognostic significance of FDG-PET imaging for patients with nonsmall cell lung carcinorma. Cancer 83:918-924, 1998. (1998)

Mathew RJ, Wilson WH, Coleman RE, Turkington TG, DeGrado TR: Marijuana intoxication and brain activation in marijuana smokers. Life Sci 60(23): 2075-2089. 1997. (1997)

Lowe VJ, Duhaylongsod FG, Patz EF, Delong DM, Hoffman JM, Wolfe WG, Coleman RE: Pulmonary abnormalities and PET data analysis: A retrospective study. Radiology 202:435-439, 1997. (1997)

Lee VS, Martinez S, Coleman RE: Primary muscle Lymphoma: Clinical and imaging findings. Radiology 203:237-244, 1997. (1997)

Coleman RE Editorial: Camera-based PET: the best is yet to come. J Nucl Med 38(11):1796-1797, 1997. (1997)

Wang H, Jaszczak RJ, Coleman RE: Monte carlo modeling of penetration effect for iodine-131 pinhole imaging. IEEE Trans Nucl Sci 43(6):3272-3277, 1996. (1996)

Tourassi GD, Floyd CE, Coleman RE: Improved noninvasive diagnosis of acute pulmonary embolism with optimally selected clinical and chest radiographic findings. Acad Radiol 3:1012-1018, 1996. (1996)

Berry CR, Garg PK, DeGardo TR, Hellyer P, Weber W, Garg S, Hansen B, Zalutsky MR, Coleman RE: Para F-18 fluorobenzylguanidine kinetics in a canine coronary artery occlusion model. J Nucl Cardiol 3(2):119-129, 1996. (1996)

Turkington TG, Hoffman JM, Jaszczak RJ, MacFall JR, Harris CC, Kilts CD, Pelizzari CA, Coleman RE: Accuracy of surface fit registration for PET and MR brain images using full and incomplete brain surfaces. J Comput Assist Tomogr 19(1):117-124, 1995. (1995)

Marks LB, Spencer DP, Sherouse GW, Bentel G, Clough R, Vann K, Jaszczak R, Coleman RE, Prosnitz LR: The role of three dimensional functional lung imaging in radiation treatment planning: The functional dose-volume histogram. Int J Radiat Oncol Phys. 33:65-75, 1995. (1995)

Duhaylongsod FG, Lowe VL, Patz EF Jr, Vaughn AL, Coleman RE, Wolfe WG: Lung tumor growth correlates with glucose metabolism measured by fluoride-18 fluorodeoxyglucose positron emission tomography. Ann Thorac Surg 60:1348-1352, 1995. (1995)

Bigner DD, Brown M, Coleman RE, Friedman AH, Friedman HS, McLendon RE, Bigner SH, Wikstrand DJ, Pegram CN, Kerby T, Zalutsky MR: Phase I studies of treatment of malignant gliomas and neoplastic meningitis with I-131 radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitan proteoglycan sulfate Mel-14 F(ab')2 - a preliminary report. J Neuro Oncol 24:109-122, 1995. (1995)