Jon P. Gockerman, MD

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Services

• Bone and Soft Tissue Cancer
• Leukemias and Lymphomas

Department / Division:
Medicine / Medical Oncology

Address:
DUMC 3872
Durham, NC 27710

Appointment Telephone:
(919) 684-8964

Office Telephone:
(919) 684-8964

Fax Telephone:
(919) 684-5325

• M.D., University of Chicago, 1967

• Internal Medicine, Duke University Medical Center, North Carolina, 1967-1969
• Hematology/Oncology, Duke University Medical Center, North Carolina, 1969-1976

Clinical Interests:
Lymphoma, leukemia, rare and complicated hematology and oncology problems

Research Interests:

My research effort is involved in clinical research studies through the CALGB as well as several sub interests. My interest is the use of 131I MIBG in the treatment of carcinoids. We have completed a dose seeking study to determine the maximum tolerated dose. This has been completed and this paper is in preparation for publication. We plan to do an additional study of randomization in patients with this agent to see if we can determine an objective response rate in a controlled group of patients.

The secondary issue is that of high dose chemotherapy in lymphoma. We have completed a study involving use of high dose chemotherapy in a transplant setting in patients with refractory lymphoma. This study has treated over 100 patients and is in the process of being written up.

Representative Publications:
Imrnunodeficiency and Expanded Population of Granular Lymphocytes After Bone Marrow Transplantation. JC Barton, EF Prasthofer, JP Gockerman, and CE Grossi. American Journal of Medicine, 82:1086 1087, 1987. (1987)

Altered Immunologic Reconstitution after Standard Dose Chemotherapy or High Dose Chemotherapy with Autologous Bone Marrow Support. GA Olsen, JP Gockerman, RC Bast, Jr., MJ Borowitz, and WP Peters. Transplantation, 46(1):57 -60, July, 1988. (1988)

Production of a Novel Anticoagulant by Neoplastic Plasma Cells. PA Kautman, JP Gockerman, and CS Greenberg. The American Journal of Medicine, 86:612 616, May, 1989. (1989)

Phase I Studies of Recombinant Interferon Gamma. J. Laszlo, D. Goldstein, J. Gockerman, L. Hood, A. Huang, P. Triozzi, WD Sedwick, H. Koren, EH Ellinwood, and CY Tso. Journal of Biological Response Modifiers, 9: 185 193, 1990. (1990)

The use of Prophylactic Eye Drops During High Dose Cytosine Arabinoside Therapy. GN Higa, JP Gockerman, AL Hunt, MR Jones, and BJ Home. Cancer, 68(8):1691 1693, October 15, 1991. (1991)

The Radiographic Diagnosis and Treatment of Paraneoplastic Central Nervous System Disease. MJ Glantz, H Biran, ME Myers, JP Gockerman, and MH Friedberg. Cancer, 73(1):168-175, 1994. (1994)

Primary central nervous system Iymphoma with systemic metastasis: case report and review. MT Brown, RE MeClendon, and JP Gockerman. J Neuro Onc 23;207-221, 1995. (1995)

Iodinee metaiodobenzylguanidine uptake in metastatic carcinoid tumor to the orbit. MW Hanson, AM Schneider, DS Enterline, JM Feldman, JP Gockerman. J Nucl Med 39 647-650, 1998. (1998)

Phase II Evaluation of Aclarubin (Aclacinomyin A) in Refractory Multiple Myeloma: A Southeastern Cancer Group Trial. JP Gockerman, HR Silberman, and AA Bartolucci. Cancer Treatment Reports, 71:7 8, 1987. (1987)

Effects of Gamma Interferon on the Endocrine System. D. Goldstein, JP Gockerman, R Krishnan, J Ritchie, CY Tso, LE Hood, E. Ellinwood, J. Laszlo. Cancer Research, 47:6397-6401, December 1, 1987. (1987)

Comparison of the Efficacy of a 2 Day and a 5 Day Schedule for Infusing Intravenous Gamma-Globulin in the Treatment of Immune Thrombocytopenic Purpura in Adults. R Kurlander, R.Siegal, RE Coleman, J. Moore, JP Gockerman, and W. Rosse. American Journal of Medicine.83:17 24, 1987. (1987)

High Dose Combination Alkylating Agents with Bone Marrow Support as Initial Treatment for Metastatic Breast Cancer. WP Peters, EJ Shpall, RB Johnson, JP Gockerman, RC Bast, and JO Moore. Autologous Bone Marrow Transplantation Proceedings of the 3rd International Symposium, 465 474, 1987. Journal of Clinical Oncology, 6(9):1368 1376, September, 1988. (1988)

Evidence For A Selective Antileukemia Effect of Cytosine Arabinoside in Chronic Granulocytic Leukemia. JE Sokal, JP Gockerman, and SH Bigner. Leukemia Research, 12(6):453-458, July, 1988. (1988)

Clinicopathologic and Cytogenetic Features of CD34 (My 10) Positive Acute Non-lymphocytic Leukemia. MJ Borowitz, JP Gockerman, JO Moore, CI Civin, SO Page, J.Robertson, and SH Bigner. American Journal of Clinical Pathology, 91(3):265- 270, March,1989. (1989)

High Dose Combination Cyclophosphamide, Cisplatin, and Melphalan with Autologous Bone Marrow Support: a Clinical and Pharmacologic study. WP Peters, A. Stuart, M. Klotman, C. Gilbert, BB Jones, EJ Shpall, JP Gockerman, R. Bast, and JO Moore. Cancer Chemotherapy and Pharmacology, 23:377 383, 1989. (1989)

The Duke AFM Program. Intensive Induction Chemotherapy for Metastatic Breast Cancer. RB Jones, EJ Shpall, J. Shogan, ML Affronti, D. Coniglio, L. Hart, E. Halperin, JD Iglehart, J. Moore, JP Gockerman, RC Bast, and WP Peters. Cancer, 66:431-436, 1990. (1990)

Improved survival in advanced Hodgkin's disease with the use of combined modality therapy.DM Brizel, EP Winer, LR Prosnitz, J Scott, J Crawford, JO Moore and JP Gockerman. International Journal of Radiation Oncology, Biology, Physics, 19(3):535 -542, 1990. (1990)

Fluconazole and Candida Krusei Fungemia. DA Persons, M. Laughlin, D. Tanner, J. Perfect, JP Gockerman, and J. Hathorne. New England Journal of Medicine. 325(18):1315, October 31, 1991. (Letter to Editor) (1991)

Parenteral Anticoagulation with the Heparinoid Lomoparan (ORG 10172) in Patients with Heparin Induced Thrombocytopenia and Thrombosis. TL Ortel, JP Gockerman, RM Califf, RL McCann, CM O'Connor, DM Metzler, and CS Greenberg. Thrombosis and Haemostasis, 67(3):292 296, 1992. (1992)

A Pilot Study of Etoposide, Vinblastine, and Doxorubicin Plus Involved Field Irradiation in Advanced, Previously Untreated Hodgkin's Disease. DM Brizel, JP Gockerman, J Crawford, JW Hathorn, JO Moore, B Osborne, and LR Prosnitz. Cancer, 74(1): 159- 163, 1994. (1994)

Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system Iymphoma: Short duration response and multifocal intracerebral recurrence preceding radiotherapy. DH Lachance, DM Brizel, JP Gockerman, EC Halperin, PC Burger, OB Boyko, MT Brown, and SC Schold. Neurology, 44: 1721 -1727, 1994. (1994)

Nitric oxide modulation of the growth and of freshly isolated acute non lymphocytic leukemia cells.. PJ Shami, JO Moore, JP Gockerman, JW Hathorn, MA Misukonis, JB Weinberg. Leukemia Research 19:527-533(95). (1995)

Secondary Myelodysplasia and acute leukemia in breast cancer patients following autologous bone marrow transplantation. MJ Laughlin, DS McGaughey, JR Crews, NJ Chao, D Rizzieri , M Ross, JP Gockerman, C Cirrinclone, D Berry, L Mills, P Defusco, S LeGrand, WP Peters, JJ Vredenburgh. submitted to J Clin Oncl.