Understanding the Problem
Nausea is a distressful or woozy feeling of the stomach that
may be accompanied by a strong urge to throw up. Vomiting is
the throwing up of stomach contents.
These are temporary side effects of chemotherapy and
radiation therapy. These symptoms may also be caused by a bowel
obstruction.
It is natural for the person with cancer to be concerned
about nausea and vomiting. It is important for you to know that
much progress has been made over the past few years in
medications to control nausea caused by cancer treatments.
Many people have no nausea or vomiting at all after their
treatments.
Call your health care provider if you have any of
the following:
- There is blood or "coffee ground" looking material in the
vomit
- You can not keep any liquids or food down
- You are unable to take or keep your nausea medication
down
- You vomit three times an hour for more than eight
hours
- You are vomiting and you lose more than two pounds in a
day
- You have nausea that lasts for more than a few days that
keeps you from doing what is important to you
- The vomit shoots out forcefully (projectile
vomiting)
- You have severe stomach pain while vomiting
- You have signs of dehydration:
- Your mouth and tongue feel dry
- You feel light-headed, dizzy, or can’t think
clearly
- Your urine is dark yellow and you are not going to
the bathroom as often as you normally do
- You have cramps in your stomach or legs, or your
hands and feet tingle or feel like “pins and
needles”
Understanding Medications for Nausea and Vomiting
General Instructions
- Some of these medications are very
expensive. If you do not have insurance coverage for
prescriptions and the cost will make it difficult for you to
pay for them, let your health care provider know right
away
- Take the medicine on a consistent schedule as
prescribed
- If you have vomiting and cannot take medicine, call your
health care provider
- If your medicine lessens your nausea and vomiting, but
not enough so that you can eat and drink, call your health
care provider. Your medicine may need to be adjusted
- Taking your medicine 30 minutes before meals may help you
eat
Common Antinausea Medicines
The most common medications for nausea and vomiting are
listed as follows. Your health care provider will instruct you
on which ones to take, and how to take them.
Do not mix medicines without contacting your medical team.
These medicines are only available by prescription.
| Trade Name |
Generic Name |
Usual Dose |
Comments |
| *
These drugs are very effective but also very
expensive. Let your health care provider know if
you do not have a prescription plan with your health
insurance and the cost would be a burden for you. |
| Compazine® |
Prochlorperazine |
10 mg by mouth, every 4 to 6 hours; 25 mg by rectal
suppository every 4-6 hours |
May cause sleepiness or restlessness; suppositories
are good if you cannot keep down any medicines taken by
mouth |
| Phenergan® |
Promethazine |
12.5-25 mg by mouth, every 4 to 6 hours; 12.5 - 50 mg
by rectal suppository every 4 to 6 hours |
May cause dizziness or drowsiness; suppositories are
good if you cannot keep down any medicines taken by
mouth |
| Ativan® |
Lorazepam |
0.5-1 mg by mouth, every 4 to 6 hours |
May cause dizziness and drowsiness |
| Kytril®* |
Granisetron |
1 mg by mouth, every 12 hours |
May cause headache, diarrhea, or constipation |
| Zofran®* |
Ondansetron |
8 mg by mouth, every 12 hours |
May cause headache, dizziness, diarrhea, or
constipation |
| Emend®* |
Aprepitant |
125mg by mouth the day of chemo, 80mg by mouth, days
2 and 3 |
Potential drug interactions; recommended for only
certain chemotherapies or after the medicines above do
not work; may cause dizziness, drowsiness, diarrhea, or
constipation |
Eating and Drinking When Nauseated
If the nausea last only a few hours, many people prefer not
to eat and to drink sips of
liquids during those hours. If the nausea lasts longer than a
few hours, it is more important to find things you can eat and
drink so you maintain your nutrition and your fluid
balance.
Most people find frequent, small, bland meals or snacks are
best. You may prefer to eat and drink foods at room
temperature. The suggestions below are based on what many
people have found helpful.
Foods that may increase nausea:
- Greasy, fatty, or fried foods
- Spicy foods (hot pepper, curry, Cajun spice mix)
- Coffee, caffeinated drinks
- Alcohol
- Acidic foods or drinks (grapefruit or orange juice)
- Foods with a lot of fiber (bran, raw vegetables, fresh
fruits, high fiber vegetables such as broccoli, corn, beans,
cabbage, peas, cauliflower), whole-grain cereals and
bread
Ways to maintain fluid balance and to prevent
dehydration
- Drink fluids between meals
- If you are not eating much, try some low fat, salty food
like pretzels or bullion as the salt helps your body hold
onto its fluids
- These fluids are usually well-tolerated:
- Gatorade®, Popsicles, Pedialyte®
- Weak tea or clear soup or broth
- Ginger ale, sodas (stir them or let them stand until
the bubbles are gone)
- Peach and apricot nectar, grape or apple juice
- Supplements such as Ensure®, Boost®, Carnation
Instant Breakfast®
Foods that are easy to eat
- Steamed white rice, mashed potatoes, boiled potatoes or
noodles
- Cream of rice or cream of wheat
- Bananas, applesauce
- Dry toast or crackers, white bread
- Baby foods, soft puddings, yogurt, cottage cheese
- Scrambled eggs
- Smooth peanut butter
- Chicken or turkey without the skin, lean beef, boiled or
baked fish
Things to Do That May Help with Nausea
- Get rest and try relaxing activities as a
distraction
- Try fluids two hours after vomiting
- Nibble on dry crackers
- Avoid unpleasant or strong odors. Some people cannot
tolerate the smell of food being cooked in their home
- Use frequent mouth rinses to remove unpleasant
tastes
- Go outside of home for fresh air as taking in more oxygen
may calm stomach
- Wear loose fitting clothes so as not to add pressure to
stomach or throat
This article is intended as a resource for patients
receiving their cancer care at Duke University Hospital or Duke
Clinic. It is not intended to substitute for medical advice
from your healthcare team. If your doctor’s instructions differ
from the information in this article, please talk with your
doctor before making any changes.
10/06